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LAMIVUDINE,ZIDOVUDINE
This page provides concise information on the medication lamivudine/zidovudine, including its indications, dosage and administration details, mechanism of action, associated brands with their strengths, as well as warnings and commonly observed side effects.
Background and Date of Approval
Lamivudine/Zidovudine is a combination medication that incorporates the active ingredients lamivudine and Zidovudine. It is employed in the treatment of HIV-1 infection in conjunction with other medications. HIV-1 specifically attacks and damages immune system cells, leading to a diminished ability of the body to combat infections, and in critical instances, it can lead to fatality.
Individuals experiencing neutropenia (low white blood cells) or anemia (low red blood cells) should refrain from using zidovudine or lamivudine. It is crucial to inform your doctor if you have any liver conditions, including hepatitis B or C, kidney disease, or if you are overweight. Both lamivudine and zidovudine obtained distinct approvals from the U.S. Food and Drug Administration (FDA). Lamivudine was granted FDA approval on November 17, 1995, while zidovudine received approval on March 19, 1987.
AVAILABLE BRANDS
ZIDOVUDINE+LAMIVUDINE TAB
Mechanism of Action of Lamivudine,zidovudine
The action of Lamivudine and Zidovudine involves the inhibition of the reverse transcriptase enzyme, a crucial component for the replication of HIV. Through this mechanism, these drugs impede viral replication, leading to a reduction in the viral load within the body. This not only slows down the progression of HIV infection but also preserves immune function, consequently lowering the risk of developing complications related to AIDS.
Uses of Lamivudine,zidovudine
Lamivudine and Zidovudine are prescribed for the management of HIV-1 infection.
Lamivudine,zidovudine Drug administaration and Dosage available
Lamivudine and Zidovudine capsules or tablets are administered orally. Typically, the medication is taken once daily as prescribed by your healthcare provider, with or without food. It is essential to swallow the capsule or tablet whole without crushing or chewing it.
Warnings, Precautions and Side Effects of Lamivudine,zidovudine
Warnings
Lamivudine and zidovudine come with various significant warnings. These encompass the potential for lactic acidosis and hepatomegaly with steatosis, hematologic toxicity, hepatotoxicity in those with pre-existing liver conditions, immune reconstitution syndrome, possible drug interactions, pancreatitis, mitochondrial toxicity, alterations in the immune system, hypersensitivity reactions, and special considerations for usage during pregnancy.
Precautions
Ensure you communicate with your healthcare provider regarding all medications, including over-the-counter drugs and herbal supplements, to prevent possible drug interactions. Moreover, adhere to the dosage and monitoring instructions provided by your healthcare provider. Attend regular check-ups to evaluate your response to the medications and promptly address any concerns that may arise.
Side Effects
Lamivudine and Zidovudine may result in side effects, including nausea, vomiting, headache, diarrhea, fatigue, muscle pain, insomnia, rash, loss of appetite, abdominal pain, and joint pain. While less frequent, these medications can also give rise to more severe side effects such as severe allergic reactions, lactic acidosis, hepatotoxicity, blood disorders, and pancreatitis.
Word Of Advice
Consulting a healthcare provider is essential before using Lamivudine and Zidovudine. If unusual side effects occur while using this medication, inform the healthcare provider. Prior liver conditions, including hepatitis B or C, kidney disease, or being overweight, should be communicated to the doctor. It is crucial to consult the doctor before using these medications during pregnancy or breastfeeding. For any health-related inquiries, it is advisable to seek guidance from a healthcare provider.
Disclaimer
The drug information on this page is different from medical advice. It is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you can receive this treatment.