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Introduction to Pemgem 100mg Injection
The Pemgem 100mg injection is a cancer-fighting medication that includes Pemetrexed as its active component. Classified as an antifolate agent, it is employed in the treatment of non-small cell lung cancer and malignant pleural mesothelioma, both of which are cancers affecting the lungs and chest. This medication can be administered independently or alongside other anticancer drugs like cisplatin. To mitigate potential side effects, your physician might recommend the use of corticosteroids, folic acid, and vitamin B12.
Prior to each infusion, blood tests will be conducted to assess the adequacy of your kidney and liver functions, as well as the presence of a sufficient number of blood cells for the administration of this medication. Before commencing treatment with the Pemgem 100mg injection, it is crucial to inform your doctor about any current or past instances of kidney issues, heart disorders, or fluid accumulation in the lungs. Additionally, report any recent or ongoing radiotherapy or vaccinations to your physician before initiating this medication.
Notify your physician promptly if you are considering pregnancy or suspect that you might be pregnant. Employ reliable contraception throughout the treatment period and for a minimum of six months following the final administration of the Pemgem 100mg injection. For men, it is advisable to refrain from fathering a child during the treatment and up to three months afterward. Consult your doctor for guidance on fertility concerns. This medication is not recommended for individuals under 18 years of age, including adolescents and children.
Uses of Pemgem 100mg Injection
- Malignant pleural mesothelioma
- Non-small cell lung carcinoma
Therapeutic Effects of Pemgem 100mg Injection
Pemgem 100mg hinders the process necessary for cell division and replication by obstructing specific enzymes crucial in folate metabolism (essential for cell replication) and DNA synthesis. This action prevents the growth and multiplication of cancer cells.
Interaction of Pemgem 100mg Injection with other drugs
Notify your healthcare provider about all your medications, including prescribed drugs, over-the-counter medicines, nutritional or vitamin supplements, and herbal products. Some medications, like [insert specific medication], may interact with Pemgem 100mg, potentially diminishing its effectiveness and causing undesirable side effects.
More Information about Pemgem 100mg Injection
- Keep the tablets away from light and moisture.
- Store refrigerated at 2°C to 8°C.
- Keep the tablets out of the reach of children and animals.
How to consume Pemgem 100mg Injection
The Pemgem 100mg injection is delivered through intravenous infusion into the vein. If this injection is prescribed for you, a healthcare professional will administer it. Refrain from self-administration. Your doctor will determine the appropriate dosage and administration frequency based on your medical condition, as it varies for each individual.
Safety Advices for Pemgem 100mg Injection
Pregnancy
Avoid taking Pemgem 100mg if you are pregnant, as it may pose risks to the unborn baby. Prior to initiating the treatment, consult with your doctor.
Breast Feeding
Breastfeeding is not advisable during the course of Pemgem 100mg treatment, as it may lead to toxicity in the baby. If you are currently breastfeeding, it is necessary to discontinue this practice. Seek guidance from your physician for further advice.
Lungs
If you encounter symptoms such as shortness of breath, blockage, or inflammation in the lining of the lung while using Pemgem 100mg, consult your doctor for guidance.
Liver
Notify your doctor of any pre-existing liver disorders prior to using Pemgem 100mg, as this medication should be approached with caution in patients with liver disease.
Alcohol
The safety of consuming alcohol while undergoing Pemgem 100mg injection treatment is uncertain. Kindly discuss this matter with your physician.
Driving
Engaging in activities such as driving or operating machinery is not recommended while taking Pemgem 100mg, as it may induce symptoms like nausea, fatigue, vomiting, etc. For further information, consult your doctor.
Side Effects of Pemgem 100mg Injection
Side effects refer to undesired symptoms triggered by medications. While all medicines can lead to side effects, not everyone experiences them.
Serious:
- Blood infection
- Severe allergic reaction
- Breathlessness, intense chest pain or cough with bloody sputum
- Reduced neutrophil granulocytes (white blood cells)
- Kidney failure
- Pharyngitis (a sore throat)
- Abnormal liver function
Common:
- Fatigue
- Nausea, vomiting, diarrhea
- Redness, swelling or sores in the mouth
- Loss of appetite, sensation
- Reduced hemoglobin level
- Increased skin pigmentation
- Watery and inflamed eyes, taste change
- Fever
- Muscle weakness
- Dehydration
- Constipation
- Skin rash
- Hair loss
Word of Advice
Discuss your fertility concerns with the doctor, especially for men, as it is recommended to refrain from fathering a child during the treatment and the subsequent three months. Seek advice on fertility matters and avoid planning for pregnancy during this period. If you encounter any side effects mentioned, consult your doctor promptly. Notify your doctor immediately if you have undergone radiotherapy, received vaccines, or taken other medications before starting Pemgem 100mg, as it could impact the effectiveness and lead to side effects. Additionally, inform your doctor about any history of heart disease, kidney problems, or liver problems that you have or had.
FAQs
Q 1. What should I tell my doctor before starting Pemgem 100mg?
Prior to initiating Pemgem 100mg, it’s crucial to inform your doctor about any medical conditions you may have, particularly kidney or liver problems, and disclose all medications you are currently taking, including over-the-counter drugs and supplements.
Q 2. Can children or adults take Pemgem 100mg?
No, Pemgem 100mg is not advisable for individuals under 18 years, including children and adolescents. For further details, consult your doctor.
Q 3. How often do I need to have blood tests while on Pemgem 100mg?
Regular blood tests will be necessary while using Pemgem 100mg to oversee your blood cell counts, blood uric acid level, and kidney function.
Q 4. Can I continue my normal activities while on Pemgem 100mg?
The decision depends on your individual circumstances and well-being. It is advisable to converse with your healthcare provider about your activities and any concerns while undergoing treatment with Pemgem 100mg.
Q 5. How is Pemgem 100mg administered?
Pemgem 100mg is administered by a healthcare provider through an intravenous (IV) injection. The dosage and frequency of the injections will be determined based on the patient’s condition and other relevant factors.
Fact Box of Pemgem 100mg Injection
Molecule name: Pemetrexed
Pharmacological class: Antifolate agent
Therapeutic class: Anti-Cancer
Indication:
Non-small cell lung carcinoma
Malignant pleural mesothelioma
References
- KD Tripathi, Essentials of Medical Pharmacology, Anticancer drugs,7th edition, 2013, 863.
- Eagle Pharmaceuticals, US Food and Drug Administration, [ Revised on Feb 2020] [ Accessed on 27 – March – 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/209472s000lbl.pdf
- Seacross Pharmaceuticals Ltd, Electronic medicines compendium (emc), [ Accessed on 27 – March – 2023], https://www.medicines.org.uk/emc/files/pil.8887.pdf
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