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Introduction to Zidine 300mg Tablet
Zidine 300mg tablets fall under the category of nucleoside reverse transcriptase inhibitors (NRTI) and serve as an antiretroviral medication. These tablets contain the active ingredient Zidovudine and hold the distinction of being the initial antiretroviral agent sanctioned for the treatment of HIV-1 infection. Additionally, healthcare professionals may recommend this medication to prevent the transmission of the virus from the mother to the fetus.
The use of this tablet may induce bone marrow suppression, causing a reduction in the production of red blood cells, white blood cells, and platelets. This can result in conditions such as anemia, thrombocytopenia (low platelet count), and neutropenia (low white blood cell count). It is crucial to regularly monitor blood cell counts, especially in the early stages of treatment. Additionally, this medication has been linked to mitochondrial toxicity, leading to serious conditions like lactic acidosis (accumulation of lactic acid in the blood) and hepatic steatosis (fatty liver). These complications are more likely to occur in individuals with underlying liver disease, obesity, or a history of pancreatitis.
In the initial phases of HIV treatment, certain individuals may undergo an inflammatory reaction in response to opportunistic infections. This phenomenon, known as immune reconstitution syndrome, can manifest after the initiation of this drug or other antiretroviral therapies. It is imperative to be aware of this possibility and diligently observe for any indications of worsening infections or inflammatory symptoms. Should such symptoms be a cause for concern or persist longer than usual, it is essential to promptly inform your healthcare provider. In case of allergies to this drug or its components, it is recommended to refrain from its use. Prior to taking the Zidine 300mg tablet, make sure to disclose all recent medications, including herbal remedies and supplements, to your physician.
Uses of Zidine 300mg Tablet
- Human Immunodeficiency Virus (HIV)
- Prevent transmission of the virus from mother to fetus
Therapeutic Effects of Zidine 300mg Tablet
The mechanism of action of Zidine 300mg Tablet involves the inhibition of the reverse transcriptase enzyme in HIV. This restriction impedes the replication of the viral genome and diminishes the production of new infectious viral particles. The primary interference occurs during reverse transcription, and the drug plays a crucial role in inhibiting the dissemination of HIV within the body.
Interaction of Zidine 300mg Tablet with other drugs
Notify your healthcare provider about all medications you are taking, whether prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Some drugs, including ganciclovir, interferon alfa, and ribavirin, may interact with Zidine 300mg Tablet, potentially diminishing its effectiveness and leading to undesirable side effects.
More Information about Zidine 300mg Tablet
- Store Zidine 300mg Tablet at room temperature (15°to 25°C).
- Keep the tablet out of reach of children and pets.
How to consume Zidine 300mg Tablet
This is an oral prescription medication. Your doctor will determine the appropriate dosage and duration of the drug based on your medical condition and other relevant factors. Always adhere to your doctor’s prescription when taking Zidine 300mg Tablet. You can take the tablet with or without food. Ensure that you do not break, chew, crush, or split the tablet; instead, swallow it whole with water.
Safety Advices for Zidine 300mg Tablet
Pregnancy
Your doctor shall prescribe Zidine 300mg Tablet only if it is essential and the benefits outweigh the risks.
Breast Feeding
It is unsafe to take Zidine 300mg Tablet during breastfeeding because it tends to get excreted in human milk.
Liver
Consult your physician for advice before taking Zidine 300mg Tablet if you have liver problems. Ensure that your physician monitors your liver functions regularly.
Alcohol
Consuming alcohol may affect the effectiveness of Zidine 300mg Tablet. It is highly advised to stop consuming alcohol if you take this medicine.
Driving
It is unsafe to drive vehicles or operate heavy machinery after taking Zidine 300mg Tablet, it may cause dizziness and impair your concentration.
Side Effects of Zidine 300mg Tablet
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
Serious:
- Liver damage
- Hypersensitivity reactions
- Myopathy
- Lactic acidosis
Common:
- Headache
- Muscle pain
- Nausea
- Anorexia
- Vomiting
- Fever
- Cough
- Anaemia
- Neutropenia
Word of Advice
To prevent the transmission of HIV infection, refrain from sharing needles or syringes, as they can easily transmit HIV-1 infections. Individuals using injectable drugs should exclusively use sterile needles and syringes, avoiding any sharing with others. Personal items such as toothbrushes, razor blades, or anything that may have blood or body fluids should also not be shared, as HIV-1 can be present in these fluids, posing a risk of virus transmission.
Given that this drug is not recommended for breastfeeding due to the potential transmission of HIV infection through breast milk, alternative feeding methods should be employed to support the infant’s growth. In case you forget to take Zidine 300mg Tablet on a given day, resume your regular dosage the following day. However, it is essential not to double-dose.
Fact Box of Zidine 300mg Tablet
Molecule name: Zidovudine
Pharmacological class:
Nucleoside Reverse Transcriptase Inhibitor (NRTI)
Therapeutic class: Antiretroviral
Indications:
1. Human Immunodeficiency Virus (HIV)
2. Prevent transmission of the virus from mother to fetus
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