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VINBLASTINE
This page provides a concise overview of the drug vinblastine, including its indications, dosage and administration, mechanism of action, associated brands with their strengths, warnings, and common side effects.
Background and Date of Approval
Vinblastine is an anticancer medication classified as a mitotic inhibitor. It received U.S. FDA approval in 1962 for the treatment of Hodgkin’s and non-Hodgkin’s lymphoma.
Mechanism of Action of Vinblastine
Vinblastine works by disrupting the formation of microtubules in cells. Microtubules are structures that support and shape cells and transport molecules within them. In cancer cells, microtubules are crucial for cell division and growth. By interfering with microtubule formation, vinblastine prevents cancer cells from dividing and growing, ultimately causing their death.
Uses of Vinblastine
Vinblastine is used to treat Hodgkin’s and non-Hodgkin’s lymphoma, testicular cancer, breast cancer, and Kaposi’s sarcoma.
Vinblastine Drug administaration and Dosage available
A healthcare professional will administer the medication in a hospital setting. Vinblastine is given as an intravenous infusion over 30 minutes, typically once a day for up to 5 days. Your doctor will determine the dose, route of administration, and frequency based on your specific condition and other factors.
Warnings, Precautions and Side Effects of Vinblastine
Warnings
Do not take this injection if you are allergic to vinblastine or any of its ingredients. Use this injection with caution if you have a history of nerve damage, respiratory disease, or gastrointestinal disorders. Special care is needed if you are taking other medications, as some may interact with vinblastine. For instance, erythromycin may increase its side effects. If you are undergoing radiotherapy in the liver area, your doctor will delay administering this medicine. During treatment, your doctor may periodically monitor your white blood cell counts, platelets, blood sugar, electrolytes, and kidney function to prevent serious complications. This medication can cause heart problems when combined with other anticancer drugs such as bleomycin or cisplatin.
Precautions
Due to the risk of birth defects, women of childbearing potential should use effective contraception during treatment with this drug. If you are pregnant, breastfeeding, planning to have a baby, or think you may be pregnant, consult your doctor for advice before taking this medicine. Avoid driving or operating machinery if you experience any side effects that may impair your ability to do so.
Do not use this injection if you are allergic to vinblastine or any of its ingredients, have an uncontrolled bacterial infection, or if your blood tests show insufficient white blood cells to fight infection. This drug can cause changes in your blood cells, so your doctor will monitor your blood samples and liver function during treatment. Inform your doctor if you have been diagnosed with liver disorders, heart failure, high blood cholesterol levels, or hypertension before starting this treatment.
Side Effects
Common side effects of vinblastine treatment include tiredness, diarrhea, hair loss, stomach cramps, loss of appetite, nausea, and vomiting. Serious side effects can include swelling or pain at the injection site. If you experience any allergic or unusual reactions, contact your doctor immediately.
Word Of Advice
Vinblastine can weaken the immune system, making patients more susceptible to infections. Patients should take steps to avoid contact with sick individuals and practice good hygiene, such as frequent handwashing. Additionally, avoid activities that could increase the risk of injury or bleeding, such as contact sports or using sharp objects.
This drug also increases skin sensitivity to sunlight, which can lead to sunburn, blistering, or skin discoloration. It is important to use sunscreen and wear protective clothing when exposed to sunlight. Limiting or avoiding alcohol intake while taking vinblastine is recommended.
Because vinblastine increases the likelihood of bruising, exercise caution when using sharp objects or engaging in activities that could result in injury.
Disclaimer
The drug information on this page is different from medical advice. It is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you can receive this treatment.