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Introduction to Acaone 100mg Capsule
Acaone 100mg Capsule is an anticancer medication comprising the active ingredient Acalabrutinib. It falls within the category of drugs known as Bruton’s tyrosine kinase (BTK) inhibitors and is employed in the treatment of mantle cell lymphoma (MCL), chronic lymphocytic leukemia (CLL), and small lymphocytic lymphoma (SLL). These conditions involve cancers of the white blood cells known as lymphocytes, integral components of the immune system. The distinctions between MCL, CLL, and SLL lie in the specific location of cancer occurrence and the type of lymphocytes affected.
Prior to commencing this medication, disclose to your doctor any recent surgery, bleeding issues, heart rhythm irregularities, infections, pregnancy, or breastfeeding. Its usage is not advisable for individuals under the age of 18, including children and adolescents. This medication may elevate the risk of bleeding. Patients utilizing Acaone 100mg Capsule should undergo monitoring for indications of bleeding and abstain from concurrent use of other medications that could amplify the risk of bleeding, such as blood thinners.
Uses of Acaone 100mg Capsule
The Acaone 100mg Capsule is used in the treatment of
- Chronic lymphocytic leukemia
- Small lymphocytic lymphoma
- Mantle cell lymphoma
Therapeutic Effects of Acaone 100mg Capsule
Acaone 100mg Capsule exerts its therapeutic impact by suppressing the activity of Bruton’s tyrosine kinase (BTK). This protein plays a crucial role in the survival and proliferation of cancer cells observed in specific lymphomas and leukemias. Through the inhibition of BTK, the medication effectively retards or halts the growth and dissemination of cancer cells. Consequently, this intervention may result in a decrease in tumor size, amelioration of symptoms, and a postponement in the progression of the disease.
Interaction of Acaone 100mg Capsule with other drugs
Notify your healthcare provider about all the medications you are taking, whether they are prescription, over-the-counter, nutritional or vitamin supplements, or herbal products. Some drugs may interact with Acaone 100mg Capsule, potentially diminishing its effectiveness and leading to undesirable side effects.
More Information about Acaone 100mg Capsule
- Store in a refrigerator between 20°C to 25°C (68°F to 77°F).
- Keep away from moisture, heat, and light.
- It should not be frozen.
- Keep it in its original packaging until it is ready to be used.
- Keep out of the reach of children and pets.
How to consume Acaone 100mg Capsule
Acaone 100mg Capsule is generally administered orally, either with or without food. It is essential to swallow the tablets whole and not crush, chew, or break them. The prescribed dosage may vary based on the specific type of cancer being addressed and individual factors such as overall health and response to treatment. It is crucial not to double the dosage to compensate for a missed dose.
Safety Advices for Acaone 100mg Capsule
Pregnancy
The use of Acaone 100mg Capsule is contraindicated during pregnancy due to the potential harm it may cause to the developing fetus. It is strongly advised to refrain from becoming pregnant while using this medication.
Breast Feeding
The excretion of Acaone 100mg Capsule into human breast milk is uncertain. Therefore, lactating women should seek guidance from a healthcare professional before considering its use.
Lungs
If you are contemplating treatment with Acaone 100mg Capsule for lung disease or lung cancer, it is crucial to engage in a discussion with your healthcare provider regarding the potential advantages and risks associated with this medication.
Liver
Acaone 100mg Capsule may impact the liver, leading to an elevation of liver enzymes (AST, ALT) in certain patients. In rare instances, severe liver injury or failure has been documented.
Alcohol
Individuals using Acaone 100mg Capsule are advised to refrain from or restrict their alcohol intake, as alcohol can intensify specific side effects of the medication, including fatigue and depression.
Driving
Patients should consistently assess their reaction to Acaone 100mg Capsule and exercise caution when driving or operating machinery if they encounter any side effects that could potentially compromise their ability to do so safely.
Side Effects of Acaone 100mg Capsule
Similar to all medications, Acaone 100mg Capsule may induce certain side effects, though not everyone will necessarily encounter them.
Serious:
- Bleeding problems (bruising or bleeding)
- Infections (pneumonia and sepsis)
- High blood pressure
- Heart problems (irregular heartbeat and chest pain)
- Kidney failure
Common:
- Headache
- Diarrhea
- Nausea
- Fatigue
- Muscle and joint pain
- Bruising or bleeding easily
- Upper respiratory tract infection
- Rash or itching
Word of Advice
If Acaone 100mg Capsule has been prescribed to you, it is crucial to meticulously read and comprehend the warnings and precautions associated with the medication. Regular monitoring for signs of allergic reactions is essential. The medication has the potential to induce high blood pressure, necessitating regular blood pressure checks. Any development of skin lesions or alterations in appearance should be promptly reported to your doctor. Due to an increased risk of infection, close contact with infected individuals should be avoided. Patients with diabetes should undergo careful monitoring throughout the treatment. Pregnancy and breastfeeding are contraindicated during this course of treatment. Maintaining a healthy and well-balanced diet is advised to support overall health and well-being.
FAQs
Q 1. Can I take Acaone 100mg Capsule if I have a history of bleeding disorders?
Individuals with a background of bleeding disorders might face an elevated risk of bleeding when using Acaone 100mg Capsule. Prior to initiating treatment, your healthcare provider will assess your susceptibility to bleeding and might suggest additional monitoring or precautions.
Q 2. Can I take Acaone 100mg Capsule if I have a history of heart disease?
Acaone 100mg Capsule may result in cardiac effects, such as irregular heartbeat and atrial fibrillation. Individuals with a history of heart disease should undergo close monitoring during its administration. Your healthcare provider might advise additional surveillance or precautions in such cases.
Q 3. How will this medication affect my blood?
Acaone 100mg Capsule can influence your blood composition in various ways, potentially causing a reduction in the counts of red blood cells, white blood cells, and platelets. This may result in conditions like anemia, susceptibility to infections, and an increased risk of bleeding. Your healthcare provider will conduct regular monitoring of your blood counts both before and during the course of treatment.
Q 4. Can I take this medication if I have diabetes?
Patients with diabetes can use Acaone 100mg Capsule, but it is crucial to diligently monitor blood sugar levels during its administration. The medication may lead to an elevation in blood sugar levels for some individuals, potentially necessitating adjustments in diabetes medications or insulin dosages.
Q 5. Can I go for Tooth extraction while taking this medication?
Patients using Acaone 100mg Capsule should notify both their dentist and healthcare provider in the event of requiring a tooth extraction or other dental procedures. This is important due to the medication’s potential to heighten the risk of bleeding and impede wound healing. Your dentist and healthcare provider might suggest a temporary cessation of treatment before the dental procedure to mitigate the risk of bleeding.
Fact Box of Acaone 100mg Capsule
Molecule name: Acalabrutinib
Pharmacological class: Bruton’s tyrosine kinase (BTK) inhibitors
Therapeutic class: Antineoplastic
Indications:
1. Chronic lymphocytic leukemia
2. Small lymphocytic lymphoma
3. Mantle cell lymphoma
1. Chronic lymphocytic leukemia
2. Small lymphocytic lymphoma
3. Mantle cell lymphoma
References
- AstraZeneca, Electronica medicines compendium (EMC), [Revised on Dec 2020], [ Accessed on 5th May 2023], https://www.medicines.org.uk/emc/files/pil.11917.pdf
- AstraZeneca, US Food and Drug Administration, [ Revised on Oct 2017], [ Accessed on 5th May 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/210259s000lbl.pdf
- John C Byrd et al; Acalabrutinib monotherapy in patients with relapsed/refractory chronic lymphocytic leukemia: updated phase 2 results; Blood; Published on April 2020; [Accessed on5th May 2023]; https://pubmed.ncbi.nlm.nih.gov/31876911/
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