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Introduction to Amfosted 500mg Injection
Amfosted 500mg injection comprises the active ingredient Amifostine and falls under the category of medications known as adjunct chemoprotective agents. It is employed to shield the kidneys from the detrimental effects of the chemotherapy drug cisplatin when administered to patients undergoing ovarian cancer treatment. Additionally, it is utilized to alleviate dryness in the mouth resulting from radiation treatment following surgery for head and neck cancer. The mechanism of action involves safeguarding against the adverse effects of both chemotherapy medications and radiation treatment. Prior to commencing therapy, it is essential to inform your healthcare professional of any history of low blood pressure, stroke, seizures, or other complications.
Avoid taking Amfosted 500mg injection if you have an allergy to Amifostine or any of its components. Notify your physician immediately if you experience a red itchy rash and hives on the skin following the injection. Refrain from using this medication if you are pregnant or planning pregnancy. Inform your physician about any history of liver disease, kidney disease, heart disorders, heart failure, or heart rhythm changes. Common side effects include reduced blood pressure, nausea, and vomiting. If you are planning pregnancy, discuss potential impacts on fertility with your doctor.
Uses of Amfosted 500mg Injection
- Protect the kidneys from the harmful effects of chemotherapy medication
- Treatment of dryness in the mouth after head and neck cancer
Therapeutic Effects of Amfosted 500mg Injection
The primary metabolite in Amfosted 500mg injection is accountable for the majority of cytoprotective and radioprotective effects. It efficiently permeates cells, binding to and neutralizing reactive platinum and alkylating agent metabolites while also scavenging free radicals. Additional effects encompass the inhibition of cell death, alteration of gene expression, and modification of enzyme activity.
Interaction of Amfosted 500mg Injection with other drugs
Notify your healthcare provider about all the medications you are currently using, including prescription drugs, over-the-counter medications, nutritional and vitamin supplements, as well as herbal products. Some medications may interact with Amfosted 500mg injection, diminishing its effectiveness and causing undesirable side effects. It is particularly crucial to inform your physician if you are taking any medications for heart problems.
More Information about Amfosted 500mg Injection
- Store the injection at room temperature 20°C to 25°C
- Protect the medicine from light and excessive moisture.
- Keep the medicine out of reach of children and pets
- If you missed the dosing schedule, inform your healthcare professional immediately and reschedule.
How to consume Amfosted 500mg Injection
Amfosted 500mg injection will be administered by a doctor or another healthcare professional in a hospital setting with expertise in cancer chemotherapy. The dosage, route of administration, and duration of the therapy will be determined by your doctor, considering factors such as your disease status, severity, body weight, other medical conditions, and age. The injection will be given intravenously, directly into your vein. It is crucial not to self-administer the injection.
Safety Advices for Amfosted 500mg Injection
Pregnancy
Do not take Amfosted 500mg injection if you are pregnant because this may harm the unborn baby. Inform your physician if you are pregnant, suspecting pregnancy, or planning to get pregnant during the treatment. Use effective contraception during the treatment.
Breast Feeding
Breastfeeding is not recommended in patients taking Amfosted 500mg injection because the medicine passes into the breast milk in small amounts and may harm your baby. Do not breastfeed during the treatment.
Liver
There is limited information available on the use of Amfosted 500mg injection in patients with liver disease. Please consult your doctor if you have any liver diseases.
Alcohol
It is unsafe to consume alcohol with Amfosted 500mg injection because it may affect the effectiveness of the therapy.
Driving
It is not known whether Amfosted 500mg injection alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Consult your doctor for more advice.
Side Effects of Amfosted 500mg Injection
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
Common
- Skin rash
- Nausea
- Vomiting
Serious
- Decreased blood pressure
- Severe skin rash
- Severe hypersensitivity reaction
Word of Advice
Drink extra fluids during the 24 hours before you receive this medicine. You may be advised to take calcium supplements and other medications to help prevent nausea and vomiting. Do not smoke or consume alcohol while using this medicine. Your doctor may advise you to take certain blood tests during the treatment to monitor any unwanted side effects.
FAQs
Q 1. Can a patient with kidney problems take Amfosted 500mg injection?
Amfosted 500mg injection is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of this injection may not be needed in kidney disease patients. Please consult your doctor for more advice.
Q 2. Is hypotension a side effect of Amfosted 500mg injection?
Low blood pressure (hypotension) may occur with Amfosted 500mg injection. Report to your doctor immediately if you have any symptoms of blurred vision, confusion, severe dizziness, faintness, lightheadedness, sweating, or unusual tiredness or weakness.
Q 3. What if I overdose or take two doses of Amfosted 500mg injection?
If you unknowingly overdosed or took two doses of Amfosted 500mg injection, immediately inform your healthcare professional and seek medical advice.
Q 4. What if I miss a dose of Amfosted 500mg injection?
Do not miss your dose. Keep all your appointments with the dosing regularly. In case if you forget or missed an appointment, inform your healthcare professional and reschedule the dosing.
Fact Box of Amfosted 500mg Injection
Molecule name: Amifostine
Pharmacological class: Adjunct Chemoprotective Agents
Therapeutic class: Cytoprotectant
Indications:
1. Protect the kidneys from the harmful effects of chemotherapy medication.
2. Treatment of dryness in the mouth after head and neck cancer
1. Protect the kidneys from the harmful effects of chemotherapy medication.
2. Treatment of dryness in the mouth after head and neck cancer
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